Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland. Department of Medical Sciences, University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, IIGM, Turin, Italy. MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London. Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK. Center for Life Course Health Research, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; Partner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden. Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Centre - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, Australia; Curtin UWA Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, The University of Western Australia, Crawley, Australia. Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands. Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK. Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany. Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Bavaria, Germany; Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Bavaria, Germany; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany. Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Im Neuenheimer Feld, Heidelberg, Germany; Network Aging Research, University of Heidelberg, Bergheimer Straße, Heidelberg, Germany. Telethon Kids Institute, University of Western Australia, Perth, Australia. Department of Biological Psychology, School of Public Health, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases DZNE, Site Rostock/Greifswald, Greifswald, Germany. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands. Medical School, University of Western Australia, Perth, Australia. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, Singapore; Institute of Health Sciences, University of Oulu, Finland. Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Centre, Maastricht, The Netherlands. Partner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Centre - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Microbiology and Immunology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands. Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; Durrer Centre for Cardiogenetic Research, ICIN - Netherlands Heart Institute, Utrecht, The Netherlands. Partner Site Greifswald, DZHK (German Centre for Cardiovascular Research), Greifswald, Germany. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA. Genomics of Common Disease, Department of Medicine, Imperial College London, London, UK; European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, CNRS UMR 8199, Lille, France. Department of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK; Imperial College Healthcare NHS Trust, London, UK; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Imperial College London, National Heart and Lung Institute, London, UK. Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich, Heine University, Düsseldorf, Germany. Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. Children's Hospitals and Clinics of Minnesota, Children's Minnesota Research Institute, Minneapolis, MN 55404, USA. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Cardiology, Ealing Hospital, North West Healthcare NHS Trust, London, UK; Imperial College Healthcare NHS Trust, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK. Electronic address: m.jarvelin@imperial.ac.uk. Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Medical Research Centre (MRC) Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland. Electronic address: sylvain.sebert@oulu.fi.